The Role of Retinoic Acid in Spermatogenesis and Its Application in Male Reproduction

文献类型： 外文期刊

第一作者： Zhao, Yue

作者： Zhao, Yue;Cao, Jingchao;Wu, Aowu;Chen, Mingming;Wu, Sen;Lian, Zhengxing;Deng, Shoulong;Deng, Shoulong;Li, Chongyang;Ma, Xuehai

作者机构：

关键词： retinoic acid; spermatogenesis; male reproductive disorders; male contraception; spermatogonial differentiation; meiosis

期刊名称：CELLS （ 影响因子：5.1； 五年影响因子：6.0 ）

ISSN：

年卷期： 2024 年 13 卷 13 期

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收录情况： SCI

摘要： Spermatogenesis in mammalian testes is essential for male fertility, ensuring a continuous supply of mature sperm. The testicular microenvironment finely tunes this process, with retinoic acid, an active metabolite of vitamin A, serving a pivotal role. Retinoic acid is critical for various stages, including the differentiation of spermatogonia, meiosis in spermatogenic cells, and the production of mature spermatozoa. Vitamin A deficiency halts spermatogenesis, leading to the degeneration of numerous germ cells, a condition reversible with retinoic acid supplementation. Although retinoic acid can restore fertility in some males with reproductive disorders, it does not work universally. Furthermore, high doses may adversely affect reproduction. The inconsistent outcomes of retinoid treatments in addressing infertility are linked to the incomplete understanding of the molecular mechanisms through which retinoid signaling governs spermatogenesis. In addition to the treatment of male reproductive disorders, the role of retinoic acid in spermatogenesis also provides new ideas for the development of male non-hormone contraceptives. This paper will explore three facets: the synthesis and breakdown of retinoic acid in the testes, its role in spermatogenesis, and its application in male reproduction. Our discussion aims to provide a comprehensive reference for studying the regulatory effects of retinoic acid signaling on spermatogenesis and offer insights into its use in treating male reproductive issues.

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