In-house ammonia induced lung impairment and oxidative stress of ducks

文献类型： 外文期刊

第一作者： Liu, Bo

作者： Liu, Bo;Fu, Yang;Zhao, Yue;Chen, Wenjing;Zuo, Xin;Zhu, Yongwen;Ye, Hui;Yang, Lin;Wang, Wence;Liu, Bo;Wei, Shi;Zhang, Minhong;Pan, Jie;Yang, Lin

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关键词： ammonia; duck; growth performance; trachea; lung

期刊名称：POULTRY SCIENCE （ 影响因子：4.4； 五年影响因子：4.4 ）

ISSN： 0032-5791

年卷期： 2024 年 103 卷 5 期

页码：

收录情况： SCI

摘要： Ammonia (NH 3 ) is a toxic gas that in intensive poultry houses, damages the poultry health and induces various diseases. This study investigated the effects of NH 3 exposure (0, 15, 30, and 45 ppm) on growth performance, serum biochemical indexes, antioxidative indicators, tracheal and lung impairments in Pekin ducks. A total of 288 one-day-old Pekin male ducks were randomly allocated to 4 groups with 6 replicates and slaughtered after the 21-d test period. Our results showed that 45 ppm NH 3 signi ficantly reduced the average daily feed intake (ADFI ) of Pekin ducks. Ammonia exposure signi ficantly reduced liver, lung, kidney, and heart indexes, and lowered the relative weight of the ileum. With the increasing of in-house NH 3 , serum NH 3 and uric acid ( UA) concentrations of ducks were signi ficantly increased, as well as liver malondialdehyde ( MDA), superoxide dismutase ( SOD), and glutathione peroxidase (GPX-Px ) contents. High NH 3 also induced trachea and lung injury, thereby increasing levels of tumor necrosis factor - a (TNF-a ) and interleukin-4 (IL4) in the lung, and decreasing the mRNA expressions of zonula occludens 1 (ZO-1 ) and claudin 3 (CLDN3 ) in the lung. In conclusion, in-house NH 3 decrease the growth performance in ducks, induce trachea and lung injuries and meanwhile increase the compensatory antioxidant activity for host protection.

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