文献类型： 外文期刊
第一作者： Thu, Zaw Min
作者： Thu, Zaw Min;Sun, Jian;Ji, Jingwen;He, Lili;Ji, Jinbo;Iqbal, Zafar;Myo, Ko Ko;Gao, Yuanyu;Zhai, Lijuan;Mu, Yangxiu;Tang, Dong;Yang, Haikang;Yang, Zhixiang;Thu, Zaw Min;Myo, Ko Ko;Vidari, Giovanni
作者机构：
关键词： Monobactam; Aztreonam; Antibacterial; Gram-negative
期刊名称：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS （ 影响因子：2.572； 五年影响因子：2.427 ）
ISSN： 0960-894X
年卷期： 2021 年 39 卷
页码：
收录情况： SCI
摘要： Monobactams play an important role in antibiotic drug discovery. Based on the structural characteristics of aztreonam and its biological targets, six new monobactam derivatives (2a-c and 3a-c) were synthesized and their in vitro antibacterial activities were investigated. Compounds 2a-c showed higher activities against tested gramnegative bacteria than that of parent aztreonam. Monobactam 2c exhibited the most potent activities, with MIC ranging from 0.25 to 2 jig/mL against most bacteria.
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