D-Galactose Induces Chronic Oxidative Stress and Alters Gut Microbiota in Weaned Piglets

文献类型： 外文期刊

第一作者： Han, Hui

作者： Han, Hui;Liu, Zemin;He, Liuqin;Wang, Chenyu;Hou, Ruoxin;Li, Tiejun;Yin, Yulong;Han, Hui;Liu, Zemin;Wang, Chenyu;Hou, Ruoxin;Li, Tiejun;Yin, Yulong;Yin, Jie;Gao, Jing;Gao, Jing;He, Liuqin;Yin, Yulong;He, Xingguo;Wang, Guoqiang

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关键词： D-galactose; chronic oxidative stress; gut microbiota; weaned piglets; growth performance

期刊名称：FRONTIERS IN PHYSIOLOGY （ 影响因子：3.367； 五年影响因子：3.697 ）

ISSN： 1664-042X

年卷期： 2021 年 12 卷

页码：

收录情况： SCI

摘要： Oxidative stress commonly occurs in pig production, which can severely damage the intestinal function of weaned piglets. This study was conducted to investigate the effects of D-galactose with different levels used to induce chronic oxidative stress on growth performance, intestinal morphology and gut microbiota in weaned piglets. The results showed that addition of 10 and 20 g/kg BW D-galactose reduced average daily gain and average daily feed intake from the first to the third week. 10 g/kg BW D-galactose increased the concentration of serum MDA at the second and third week. 10 g/kg BW D-galactose significantly influenced the jejunal and ileal expressions of GPx1, CAT1, and MnSOD. The results of 16S rRNA sequencing showed that compared with the control, 10 and 20 g/kg BW D-galactose significantly decreased the relative abundance of Tenericutes, Erysipelotrichia, Erysipelotrichales, and Erysipelotrichaceae, while increased the relative abundance of Negativicutes, Selenomonnadales, and Veillonellaceae. The results indicated that treatment with 10 g/kg BW/day D-galactose for 3 weeks could induce chronic oxidative stress, reduce the growth performance and alter gut microbiota in weaned piglets.

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