MicroRNA: Could It Play a Role in Bovine Endometritis?

文献类型： 外文期刊

第一作者： Umar, Talha

作者： Umar, Talha;Yin, Baoyi;Ma, Xiaofei;Jiang, Kangfeng;Akhtar, Muhammad;Shaukat, Aftab;Deng, Ganzhen;Umer, Saqib;Umar, Zaima

作者机构：

关键词： miRNA; Bovines; Inflammation; Cytokines; Endometritis

期刊名称：INFLAMMATION （ 影响因子：3.212； 五年影响因子：3.062 ）

ISSN： 0360-3997

年卷期：

页码：

收录情况： SCI

摘要： Endometritis in dairy cows is a major economic problem worldwide; without advances in lifestyle management and drug treatment, it causes high morbidity and death. Micro ribonucleic acid (miRNAs) these days is seen as an important part of gene control networks. It is a class of small nucleotides 20-25, single-stranded RNA molecules. In endometritis, the inflammatory response caused by the gram-negative bacteria Escherichia coli (E. coli) alters the expression of miRNA which can regulate the innate immune system. This manuscript reviews (1) the interaction of miRNAs with the signaling of NF-kappa B and dysregulation of miRNAs and NF-kappa B activity in endometritis and (2) the activity of miR-let-7c, miR-148a, and miR-488 in NF-kappa B activation and their effect on endometritis. Cows with reduced immunity are more vulnerable to transition diseases, such as endometritis. During post-partum, cows undergo stress, metabolic disorders, hormonal imbalance, negative energy balance, and changes in diet. One of the many categories of regulatory molecules, which explain its natural function and pathological impact on NF-kappa B dysregulation, is important to inform the complexity of the immune system and to develop treatments for endometritis. It shows that miRNAs could have multiple applications in veterinary medicine. Nevertheless, a comprehensive study of is essential which should be aimed at exploring the role of microRNA at physiological level and its effect due to dysfunction and dysregulation.

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