Aspergillus flavus's Response to Antagonism Bacterial Stress Sheds Light on a Regulation and Metabolic Trade-Off Mechanism for Adversity Survival

文献类型： 外文期刊

第一作者： Xie, Huali

作者： Xie, Huali;Jallow, Abdoulie;Yue, Xiaofeng;Wang, Xiuping;Fu, Jiayun;Mwakinyali, Silvano E.;Zhang, Qi;Li, Peiwu;Xie, Huali;Jallow, Abdoulie;Mwakinyali, Silvano E.;Zhang, Qi;Li, Peiwu;Xie, Huali;Jallow, Abdoulie;Yue, Xiaofeng;Wang, Xiuping;Fu, Jiayun;Mwakinyali, Silvano E.;Zhang, Qi;Li, Peiwu;Xie, Huali;Jallow, Abdoulie;Yue, Xiaofeng;Wang, Xiuping;Fu, Jiayun;Zhang, Qi;Li, Peiwu;Wang, Xiuping;Fu, Jiayun;Zhang, Qi;Li, Peiwu

作者机构：

关键词： Aspergillus flavus; aflatoxins; transomics; antagonism; metabolic trade-off switches; biocontrol

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：4.192； 五年影响因子：4.289 ）

ISSN： 0021-8561

年卷期： 2021 年 69 卷 16 期

页码：

收录情况： SCI

摘要： Biocontrol to combat the menace of Aspergillus flavus has gained considerable attention. However, the molecular mechanisms of A. flavus's response to antagonism biotic stress are poorly deciphered. Here, we discovered that A. flavus switches an adaptive metabolic reprogramming to ensure its adversity survival by multiomics analyses (including four omics platform). Antifungal "weapons" lipopeptides and antibacterial metabolites of imizoquin were identified. The central metabolism fluxes were significantly depleted but the expressions of most corresponding genes were considerably increased in A. flavus. Secondary metabolism that does not contribute to stress was markedly suppressed. In contrast, A. flavus antibacterial "weapon arsenal" was activated to occupy an ecological niche. Our results revealed that interlinked mitochondrial central metabolism and secondary metabolism are central to A. flavus antagonism biotic stress response. This discovery contributes to the targeted design of biocontrol agents and smart regularization of rhizosphere microbiome homeostasis to realize long-term fungi pathogen control and mitigation mycotoxin contamination.

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