Lactoferrin could alleviate liver injury caused by Maillard reaction products with furan ring through regulating necroptosis pathway

文献类型： 外文期刊

第一作者： Fan, Linlin

作者： Fan, Linlin;Wang, Fengen;Yao, Qianqian;Wu, Haoming;Wen, Fang;Wang, Jiaqi;Li, Huiying;Zheng, Nan;Fan, Linlin;Wang, Fengen;Yao, Qianqian;Wu, Haoming;Wen, Fang;Wang, Jiaqi;Li, Huiying;Zheng, Nan;Fan, Linlin;Wang, Fengen;Yao, Qianqian;Wu, Haoming;Wen, Fang;Wang, Jiaqi;Li, Huiying;Zheng, Nan

作者机构：

关键词： 5-hydroxymethylfurfural (5-HMF); furosine; lactoferrin; Maillard reaction products (MRPs); pyralline

期刊名称：FOOD SCIENCE & NUTRITION （ 影响因子：1.797； ）

ISSN： 2048-7177

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收录情况： SCI

摘要： As classical MRPs, the toxic effects of furosine, pyralline, and 5-hydroxymethylfurfural (5-HMF) in liver tissue are evaluated and the related mechanism is investigated here, and the protective effects of lactoferrin on liver injury caused by Maillard reaction products (MRPs) with furan ring are proved in vitro and in vivo. First, we detect the concentrations of furosine, pyralline, and 5-HMF in several foods using ultrahigh-performance liquid chromatography (UHPLC). Then, the effects of the three MRPs on liver cells (HL-7702) viability, as well as liver tissue, are performed and evaluated. Furthermore, the regulations of three MRPs on necroptosis-related pathway in liver cells are investigated. Additionally, the effects of lactoferrin in alleviating liver injury, as well as regulating necroptosis pathway, were evaluated. Results elucidate that lactoferrin protects liver injury caused by MRPs with furan ring structure through activating RIPK1/RIPK3/p-MLKL necroptosis pathway and downstream inflammatory reaction.

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