Gefitinib inhibits infectious spleen and kidney necrosis virus infection in vivo and vitro by blocking virus endocytosis
文献类型： 外文期刊
第一作者： Niu, Yinjie
作者： Niu, Yinjie;Fu, Xiaozhe;Lin, Qiang;Liu, Lihui;Luo, Xia;Liang, Hongru;Li, Ningqiu
作者机构：
关键词： Infectious spleen and kidney necrosis virus; Gefitinib; Inhibition; EGFR/PI3K signaling
期刊名称：AQUACULTURE （ 影响因子：3.224； 五年影响因子：3.591 ）
ISSN： 0044-8486
年卷期： 2021 年 539 卷
页码：
收录情况： SCI
摘要： Infectious spleen and kidney necrosis virus disease (ISKNVD) caused significant economic losses to the fishery industry. So it is urgent to develop an effective measure for prevention ISKNVD. In this study, we investigated the effects of gefitinib against ISKNV in vitro and vivo. The gefitinib inhibited viral protein synthesis and decreased viral titers with the dose-dependent manner in Chinese perch brain cells (CPB) cells. Gefitinib was observed to inhibit ISKNV infection by blocking ISKNV entry into CPB cells. Interestingly, gefitinib inhibited EGFR/PI3K phosphorylation and suppressed microfilament gathering induced by ISKNV. At the same time, gefitinib inhibited ISKNV infection and decreased pathogenicity of ISKNV in vivo. These results suggested that gefitinib prevented ISKNV infection by blocking virus-mediated endocytosis. This research provided potential of gefitinib for preventing ISKNVD.
分类号：
- 相关文献
作者其他论文 更多>>
-
A Novel and Effective Therapeutic Method for Treating Aeromonas schubertii Infection in Channa maculata
作者：Luo, Xia;Liao, Guoli;Fu, Xiaozhe;Liang, Hongru;Niu, Yinjie;Lin, Qiang;Liu, Lihui;Ma, Baofu;Li, Ningqiu
关键词：bacteriophage therapy; Channa maculata; Aeromonas schubertii; characterization
-
Research on a Biofilter for a Typical Application Scenario in China: Treatment of Pesticide Residue Wastewater in Orchards
作者：Zeng, Jin;Yuan, Quanchun;Xu, Wenzhi;Li, Hailong;Lei, Xiaohui;Wang, Wei;Lin, Qiang;Li, Xue;Lyu, Xiaolan;Zeng, Jin;Xu, Rui;Li, Menghui
关键词：biofilter; straw; imidacloprid; biodegradation; orchard
-
Tissue factor pathway inhibitors disrupt structures of rhabdovirus/ ranairidovirus and inhibit viral infection in Chinese perch, Siniperca chuatsi
作者：Ma, Baofu;Li, Jingkang;Fu, Xiaozhe;Liang, Hongru;Niu, Yinjie;Lin, Qiang;Luo, Xia;Liu, Lihui;Li, Ningqiu;Zhou, Jin;Li, Jingkang;Su, Jianguo;Zhang, Min
关键词：Viral diseases; Aquaculture industry; Peptides; Antiviral activity
-
Mitigating cadmium exposure risk in rice with foliar nano-selenium: Investigations through Caco-2 human cell line in-vivo bioavailability assay*
作者：Hussain, Bilal;Lin, Qiang;Hamid, Yasir;Hashmi, Muhammad Laeeq-ur-Rehman;Yang, Xiao E.;Yin, Xianyuan;Usman, Muhammad;Lu, Min;Taqi, Muhammad Imran;He, Zhenli
关键词：Cadmium; Caco-2 cell line; In -vitro assays; Laboratory try -out; Nanoparticles; Selenium
-
Insights into the role of endogenous humic acid on antibiotics bioadsorption process in wastewater: Mechanisms and potential implications
作者：Lin, Qiang;Luo, Ancheng;Yu, Chisheng;Chen, Kaiying;Hamid, Yasir;Liang, Zhiwei;Wang, Yunlong;Yang, Wenchen
关键词：Humic acids; Ofloxacin; Ciprofloxacin; Bioadsorption; Wastewater treatment
-
Co-foliar application of zinc and nano-silicon to rice helps in reducing cadmium exposure risk: Investigations through in-vitro digestion with human cell line bioavailability assay
作者：Lin, Qiang;Hamid, Yasir;Zou, Tong;Chen, Zhiqin;Hussain, Bilal;Feng, Ying;Li, Tingqiang;Yang, Xiaoe;Wang, Honhang;Lu, Min;Cao, Xuerui;He, Zhenli;Yang, Xiaoe
关键词：Rice; Cadmium; Zinc; Silicon; Bioavailability; Nanoparticles
-
Unlocking Eco-solutions: Analyzing parasitic disease resistance in Yellow River carp (Cyprinus carpio haematopterus) under different ecological treatments
作者：Pan, Houjun;Li, Yingying;Liang, Hongru;Wang, Yajun;Xie, Jun;Shi, Cunbin;Lv, Jun;Zhang, Yuanyuan;Wang, Xianke;Li, Xudong;Pan, Houjun;Shi, Cunbin
关键词：Fish; Intensive aquaculture; Mixed culture; Parasitosis occurrence; Logistic regression analysis
