文献类型： 外文期刊
第一作者： Ge, Shikun
作者： Ge, Shikun;Liu, Xiang;Zhang, Xiaoying;Ge, Shikun;Zhang, Xiaoying;Zhang, Xiaoying;Zhang, Xingxing;Zhong, Fagang;Zhang, Xiaoying
作者机构：
关键词： Antibody mimetics; IgY-peptide; Canine parvovirus (CPV); IgY-scFv; IgY technology
期刊名称：VETERINARY RESEARCH （ 影响因子：3.357； 五年影响因子：3.432 ）
ISSN： 0928-4249
年卷期： 2021 年 52 卷 1 期
页码：
收录情况： SCI
摘要： Antibody mimetics may be used for various biomedical applications, especially those for which conventional antibodies are ineffective. In this study, we developed a smaller molecular chicken IgY mimetic peptide (IgY-peptide) based on the complementarity-determining regions (CDRs) of the anti-canine parvovirus (CPV) IgY-scFv prepared previously. The mimetic peptide showed no cross-reactivity with canine distemper virus (CDV) and canine coronavirus (CCV) and showed excellent protective properties for Crandell-Rees Feline Kidney (CRFK) cells against CPV. This study is the first attempt to develop a mimetic IgY-peptide and demonstrates the ease and feasibility in generating such a novel antibody-like functional molecule for biomedical purposes.
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