Advances in the immunoescape mechanisms exploited by alphaherpesviruses

文献类型： 外文期刊

第一作者： Wang, Yimin

作者： Wang, Yimin;Ma, Caoyuan;Wang, Shan;Chen, Xuanqi;Ma, Jinyou;Wang, Lei;Sun, Yuan;Wang, Yimin;Ma, Caoyuan;Wang, Shan;Chen, Xuanqi;Ma, Jinyou;Wang, Lei;Sun, Yuan;Ma, Caoyuan;Wu, Hongxia;Qiu, Hua-Ji;Sun, Yuan

作者机构：

关键词： alphaherpesviruses; immunoescape; immune regulatory proteins; latency; signaling pathways

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：4.0； 五年影响因子：5.1 ）

ISSN：

年卷期： 2024 年 15 卷

页码：

收录情况： SCI

摘要： Alphaherpesviruses, categorized as viruses with linear DNA composed of two complementary strands, can potentially to induce diseases in both humans and animals as pathogens. Mature viral particles comprise of a core, capsid, tegument, and envelope. While herpesvirus infection can elicit robust immune and inflammatory reactions in the host, its persistence stems from its prolonged interaction with the host, fostering a diverse array of immunoescape mechanisms. In recent years, significant advancements have been achieved in comprehending the immunoescape tactics employed by alphaherpesviruses, including pseudorabies virus (PRV), herpes simplex virus (HSV), varicella-zoster virus (VZV), feline herpesvirus (FeHV), equine herpesvirus (EHV), and caprine herpesvirus type I (CpHV-1). Researchers have unveiled the intricate adaptive mechanisms existing between viruses and their natural hosts. This review endeavors to illuminate the research advancements concerning the immunoescape mechanisms of alphaherpesviruses by delineating the pertinent proteins and genes involved in virus immunity. It aims to furnish valuable insights for further research on related mechanisms and vaccine development, ultimately contributing to virus control and containment efforts.

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