A randomized double-blind clinical trial: Comparison of oclacitinib with a traditional Chinese herbal medicine product (Dihuang Guiqin capsule) in the treatment of canine atopic dermatitis

文献类型： 外文期刊

第一作者： Qin, Jun-Jie

作者： Qin, Jun-Jie;Qin, Jun-Jie;Zhu, Hao;Song, Zhe-Wen;Hou, Xiao-Jiao;Wang, Xiu-Min;Wang, Lei;Li, Jian-Xi;Li, Jian-Xi

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关键词： Canine atopic dermatitis; Traditional Chinese herbal medicine; Oclacitinib; Therapeutic effect; Recommended dosage

期刊名称：RESEARCH IN VETERINARY SCIENCE （ 影响因子：2.4； 五年影响因子：2.5 ）

ISSN： 0034-5288

年卷期： 2024 年 171 卷

页码：

收录情况： SCI

摘要： Canine atopic dermatitis (cAD) is a common chronic inflammatory skin disease, which seriously affects the quality of life for both dogs and their owners. Currently, the common therapeutic drugs in the clinic have disadvantages such as obvious adverse effects and high prices. Traditional Chinese herbal medicine (TCHM) has great potential for the treatment of cAD. The aim of this study is to compare the effects of different doses of the TCHM product (Dihuang Guiqin capsule) and oclacitinib in the treatment of cAD through a randomized, doubleblind trial. Sixty dogs diagnosed with AD were randomly and evenly divided into four groups (n = 15). The TCHM treatment group consisted of three subgroups that received three different oral doses (20, 40, and 60 mg/ kg BW), while the control group received 0.5 mg/kg BW of oclacitinib. Each group was administered twice daily for 14 consecutive days. The results showed that both TCHM and oclacitinib significantly improved cAD-induced itching (evaluated by pVAS) and skin lesions (evaluated by CADESI-04), while interleukin 31 (IL -31) concentrations decreased significantly (P < 0.05) and serum biochemical indicators returned to normal. In particular, The therapeutic effects of TCHM medium- and high -dose groups were similar to those of oclacitinib (P > 0.05). The preliminary recommended dose of Dihuang Guiqin capsule for the treatment of cAD has been determined to be 40-60 mg/kg BW twice daily for 14 consecutive days, which can be reduced to once daily as appropriate. Dihuang Guiqin capsule was safe and well tolerated, which may be a new option for the treatment of cAD.

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