The effects of fucoidans from Laminaria japonica on AAPH mediated oxidation of human low-density lipoprotein

文献类型： 外文期刊

第一作者： Li Laihao

作者： Li Laihao;Xue Changhu;Xue Yong;Li Zhaojie;Fu Xueyan

作者机构：

关键词： laminaria japonica;fucoidan fraction;low-density lipoprotein;antioxidant;cholesteryl ester hydroperoxide

期刊名称：ACTA OCEANOLOGICA SINICA （ 影响因子：1.431； 五年影响因子：1.445 ）

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收录情况： SCI

摘要： Five fucoidan fractions from Laminaria japonica with different sulfate content and molecular weight were prepared by anion-ex-change chromatography and mild acid hydrolysis. Their antioxidant effects on azo radicals 2—2'-Azobis(2-amidinopropane) dihydrochloride (AAPH) induced oxidation of human low-density lipoprotein (LDL) were evaluated by monitoring cholesteryl ester hydroperoxides (CHL-OOH) formation kinetics through reverse-phase high performance liquid chromatography (RP-HPLC) analysis. Fucoidan F - C with a low molecular mass of 2 000 ～ 8 000 and a sulfate content of 24.3% had much stronger protective antioxidant effect than other four fucoidan fractions on the hydrophilic radical AAPH induced LDL oxidation. However, the highly sulfated fucoidan fraction L - B with a molecular mass of 20 000 was completely ineffective in protecting LDL from the AAPH induced oxidation. The results suggested that both molecular mass and sulfate content of fucoidan played very important roles in their effects on the AAPH induced LDL oxidation.

分类号： P7

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