文献类型： 外文期刊
第一作者： Saif-Ur-Rehman, Muhammad
作者： Saif-Ur-Rehman, Muhammad;Faiz-Ul Hassan;Reecy, James;Deng, Tingxian
作者机构：
关键词： Runs of homozygosity; indigenous cattle; candidate genes; QTL
期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.141； 五年影响因子：1.92 ）
ISSN： 1049-5398
年卷期：
页码：
收录情况： SCI
摘要： The runs of homozygosity (ROH) were identified in 14 Pakistani cattle breeds (n = 105) by genotyping with the Illumina 50 K SNP BeadChip. These breeds were categorized into Dairy, Dual, and Draft breeds based on their utility and production performance. We identified a total of 10,936 ROHs which mainly consisted of a high number of shorter segments (1-4 Mb). Dairy group exhibited the highest level of inbreeding (F-ROH: 0.078 +/- 0.028) while the lowest (F-ROH: 0.002 +/- 0.008) was observed in Dual group. In 48 genomic regions identified with a high frequency of ROH, 207 genes were detected in the three breed groups. A substantially higher number of ROH islands detected in dairy breeds indicated the impact of the positive selection pressure over the years. Important candidate genes and QTL were detected in the ROH islands associated with economic traits like milk production, reproduction, meat, carcass, and health traits in dairy cattle.
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