Over-expression of UDP-glycosyltransferase UGT353G2 confers resistance to neonicotinoids in whitefly (Bemisia tabaci)

文献类型： 外文期刊

第一作者： Du, Tian-hua

作者： Du, Tian-hua;Liang, Jin-jin;Liu, Shao-nan;Fu, Bu-li;He, Chao;Yang, Jing;Wei, Xue-gao;Gong, Pei-Pan;Huang, Ming-jiao;Xue, Hu;Hu, Jin-Yu;Du, He;Ji, Yao;Zhang, Rong;Wang, Chao;Zhang, Cheng-jia;Yang, Xin;Zhang, You-jun;Yin, Cheng;Gui, Lian-you

作者机构：

关键词： UDP-glycosyltransferases; Bemisia tabaci; Insecticide resistance; Neonicotinoids; RNAi

期刊名称：PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY （ 影响因子：4.7； 五年影响因子：4.7 ）

ISSN： 0048-3575

年卷期： 2023 年 196 卷

页码：

收录情况： SCI

摘要： The whitefly, Bemisia tabaci, comes up high metabolic resistance to most neonicotinoids in long-term evolution, which is the key problem of pest control. UGT glycosyltransferase, as a secondary detoxification enzyme, plays an indispensable role in detoxification metabolism. In this study, UGT inhibitors, 5-nitrouracil and sulfinpyrazone, dramatically augmented the toxic damage of neonicotinoids to B. tabaci. A UGT named UGT353G2 was identified in whitefly, which was notably up-regulated in resistant strain (3.92 folds), and could be induced by most neonicotinoids. Additionally, the using of RNA interference (RNAi) suppresses UGT353G2 substantially increased sensitivity to neonicotinoids in resistant strain. Our results support that UGT353G2 may be involved in the neonicotinoids resistance of whitefly. These findings will help further verify the functional role of UGTs in neonicotinoid resistance.

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