The Critical Role of PARPs in Regulating Innate Immune Responses

文献类型： 外文期刊

第一作者： Zhu, Huifang

作者： Zhu, Huifang;Zhu, Huifang;Zheng, Chunfu;Tang, Yan-Dong;Zhan, Guoqing;Su, Chenhe;Zheng, Chunfu

作者机构：

关键词： PARP; ADP-ribosylation; innate immune responses; inflammation; NLR (NOD-like receptor)

期刊名称：FRONTIERS IN IMMUNOLOGY （ 影响因子：7.561； 五年影响因子：7.624 ）

ISSN： 1664-3224

年卷期： 2021 年 12 卷

页码：

收录情况： SCI

摘要： Poly (adenosine diphosphate-ribose) polymerases (PARPs) are a family of proteins responsible for transferring ADP-ribose groups to target proteins to initiate the ADP-ribosylation, a highly conserved and fundamental post-translational modification in all organisms. PARPs play important roles in various cellular functions, including regulating chromatin structure, transcription, replication, recombination, and DNA repair. Several studies have recently converged on the widespread involvement of PARPs and ADP-Ribosylation reaction in mammalian innate immunity. Here, we provide an overview of the emerging roles of PARPs family and ADP-ribosylation in regulating the host's innate immune responses involved in cancers, pathogenic infections, and inflammations, which will help discover and design new molecular targets for cancers, pathogenic infections, and inflammations.

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