Plant sterol ester of alpha-linolenic acid improved non-alcoholic fatty liver disease by attenuating endoplasmic reticulum stress-triggered apoptosis via activation of the AMPK

文献类型： 外文期刊

第一作者： Han, Hao

作者： Han, Hao;Xue, Tingli;Li, Jie;Guo, Yan;Li, Xiaoyu;Wang, Linqi;Pei, Liyuan;Zheng, Mingming

作者机构：

关键词： Plant sterol ester of alpha-linolenic acid; Non-alcoholic fatty liver disease; Endoplasmic reticulum stress; Apoptosis; AMPK

期刊名称：JOURNAL OF NUTRITIONAL BIOCHEMISTRY （ 影响因子：6.117； 五年影响因子：6.287 ）

ISSN： 0955-2863

年卷期： 2022 年 107 卷

页码：

收录情况： SCI

摘要： Apoptosis is a feature of progressions steatosis to nonalcoholic steatohepatitis (NASH) and can be explained by endoplasmic reticulum stress (ERS). The present study aimed to investigate the protective effects of plant sterol ester of alpha-linolenic acid (PS-ALA) on ERS-triggered apoptosis in high fat diet-fed mice and oleic acid-induced hepatocytes, and further explore the underlying mechanisms. Our results showed that PS-ALA improved Non-alcoholic fatty liver disease (NAFLD) in both in vivo and in vitro models. Moreover, PS-ALA treatment can attenuate ERS and associated apoptosis via inhibiting IRE1 alpha/TRAF2/JNK signal pathway. Furthermore, we found that the protective effect of PS-ALA on ERS-triggered apoptosis was mediated by activation of AMP-activated protein kinase (AMPK) as pretreatment with Compound C, an AMPK inhibitor, abolished the anti-apoptotic effect of PS-ALA. Taken together, our results illustrate that PS-ALA attenuating ERS-mediated apoptosis via activating AMPK, which provided new insights into the protective effect of PS-ALA in NAFLD. (C) 2022 Elsevier Inc. All rights reserved.

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