Genomic analysis reveals the population structure and antimicrobial resistance of avian Pasteurella multocida in China

文献类型： 外文期刊

第一作者： Jiang, Nansong

作者： Jiang, Nansong;Chen, Hongmei;Cheng, Longfei;Fu, Qiuling;Liu, Rongchang;Fu, Guanghua;Wan, Chunhe;Huang, Yu;Jiang, Nansong;Chen, Hongmei;Cheng, Longfei;Fu, Qiuling;Liu, Rongchang;Liang, Qizhang;Fu, Guanghua;Wan, Chunhe;Huang, Yu;Jiang, Nansong;Chen, Hongmei;Cheng, Longfei;Fu, Qiuling;Liu, Rongchang;Liang, Qizhang;Fu, Guanghua;Wan, Chunhe;Huang, Yu

作者机构：

期刊名称：JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY （ 影响因子：5.2； 五年影响因子：5.4 ）

ISSN： 0305-7453

年卷期： 2024 年 79 卷 1 期

页码：

收录情况： SCI

摘要： Objectives: To investigate the population structure and antimicrobial resistance (AMR) of avian Pasteurella multocida in China. Methods: Utilizing WGS analysis, we explored the phylogeny using a dataset of 546 genomes, comprising avian P. multocida isolates from China (n = 121), the USA (n = 165), Australia(n = 153), Bangladesh (n = 3) and isolates of other hosts from China (n = 104). We examined the integrative and conjugative element (ICE) structures and the distribution of their components carrying resistance genes, and reconstructed the evolutionary history of A: L1:ST129 (n = 110). Results: The population structure of avian P. multocida in China was dominated by the A:L1:ST129 clone with limited genetic diversity. A:L1:ST129 isolates possessed a broader spectrum of resistance genes at comparatively higher frequencies than those from other hosts and countries. The novel putative ICEs harboured complex resistant clusters that were prevalent in A:L1:ST129. Bayesian analysis predicted that the A:L1:ST129 clone emerged around 1923, and evolved slowly. Conclusions: A:L1:ST129 appears to possess a host predilection towards avian species in China, posing a potential health threat to other animals. The complex AMR determinants coupled with high frequencies may strengthen the population dominance of A:L1:ST129. The extensive antimicrobial utilization in poultry farming and the mixed rearing practices could have accelerated AMR accumulation in A:L1:ST129. ICEs, together with their resistant clusters, significantly contribute to resistance gene transfer and facilitate the adaptation of A:L1: ST129 to ecological niches. Despite the genetic stability and slow evolution rate, A:L1:ST129 deserves continued monitoring due to its propensity to retain resistance genes, warranting global attention to preclude substantial economic losses.

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