Comparative functional analysis of a new CDR1-like ABC transporter gene in multidrug resistance and virulence between Magnaporthe oryzae and Trichophyton mentagrophytes

文献类型： 外文期刊

第一作者： Wang, Jing

作者： Wang, Jing;Xiao, Chenwen;Liang, Shuang;Noman, Muhammad;Cai, Yingying;Zhang, Zhen;Zhu, Xueming;Chai, Rongyao;Qiu, Haiping;Hao, Zhongna;Wang, Yanli;Wang, Jiaoyu;Sun, Guochang;Lin, Fucheng;Bao, Guolian

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关键词： MoCDR1; TmCDR1; ABC transporters; Magnaporthe oryzae; Trichophyton mentagrophytes

期刊名称：CELL COMMUNICATION AND SIGNALING （ 影响因子：8.9； 五年影响因子：9.1 ）

ISSN：

年卷期： 2025 年 23 卷 1 期

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收录情况： SCI

摘要： Fungi are notorious for causing diseases in plants and domestic animals. ABC transporters play pivotal roles in multidrug resistance in fungi, with some ABC proteins indispensable for the pathogenicity of plant fungal pathogens. However, the roles of ABC proteins in animal pathogenic fungi, and the functional connections between ABC homologues in plant and animal pathogenic fungi are largely obscure. Here, we identified a new ABCG-1 gene, MoCDR1, in rice-blast fungus Magnaporthe oryzae. MoCDR1 disruption caused hypersensitivity to multidrugs, and impaired conidiation, appressorium formation, and pathogenicity. Subsequently, we systematically retrieved ABC proteins in animal pathogenic fungus Trichophyton mentagrophytes and identified TmCdr1, a homologue to MoCdr1. TmCDR1 effectively rescued the drug sensitivity and virulence of Delta Mocdr1 and mediated the drug resistance and animal skin infection in T. mentagrophytes. Moreover, MoCDR1 also rescued the defects in drug sensitivity and virulence of Delta Tmcdr1. MoCdr1 and TmCdr1 are conserved in structures and functions, and both involved in drug resistance and pathogenicity by analogously regulating gene expression levels related to transporter activity, MAPK signaling pathway, and metabolic processes. Altogether, our results represent the first comprehensive characterization of ABC genes in T. mentagrophytes, establishing a functional correlation between homologous ABC genes in plant and animal pathogenic fungi.

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