A Fast Method for the Simultaneous Analysis of 26 Beta-Agonists in Swine Muscle with a Multi-Functional Filter by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry

文献类型： 外文期刊

第一作者： Zhang, Lin

作者： Zhang, Lin;Jia, Qi;Liao, Guangqin;Qian, Yongzhong;Qiu, Jing;Zhang, Lin;Jia, Qi;Liao, Guangqin;Qian, Yongzhong;Qiu, Jing

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关键词： beta-agonists; swine muscle; ultra-high performance liquid chromatography-tandem mass spectrometry; multi-functional filter; QuEChERS

期刊名称：SEPARATIONS （ 影响因子：3.344； 五年影响因子：2.943 ）

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年卷期： 2022 年 9 卷 5 期

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收录情况： SCI

摘要： A rapid and simplified sample preparation method was developed for the simultaneous determination of 26 beta-agonists in swine muscle using a multi-functional filter (MFF) based on quick, easy, cheap, effective, rugged, and safe methods (QuEChERS). MFF integrated the cleanup and filter procedures, thereby significantly improving the efficiency of sample preparation compared with traditional solid-phase extraction. The sample was processed via enzymatic hydrolysis, purified with the optimized MFF containing 150 mg magnesium sulfate, 50 mg PSA, and 50 mg C18, and then analyzed using ultra-high performance liquid chromatography-tandem mass spectrometry. All procedures can be completed in 6.5 h. Good linearity (R-2 > 0.99) was detected in all analytes. The recoveries ranged from 71.2% to 118.6%, with relative standard deviations (RSDs) of less than 18.37% in all spiked concentrations. The limits of detection (LOD) and the limits of quantitation (LOQ) were 0.01-0.10 and 0.10-0.50 mu g/kg, respectively. The decision limit (CCoc) and detection capacity (CC beta) values fluctuated in the range of 3.44-25.71 and 6.38-51.21 mu g/kg, respectively. This method is a good alternative for detecting beta-agonist residues in swine muscle and can be successfully applied to the national risk monitoring of agro-product quality and safety in China.

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