Two unprecedented neuroprotective 2-(2-phenylethyl)chromone derivatives from cultivated "Qi-Nan" agarwood of Aquilaria sinensis

文献类型： 外文期刊

第一作者： Zhang, Lin

作者： Zhang, Lin;Yang, Li;Li, Wei;Chen, Hui-Qin;Yuan, Jing-Zhe;Cai, Cai-Hong;Mei, Wen-Li;Dai, Hao-Fu;Zhang, Lin;Li, Zhen-Yu

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关键词： Cultivated "Qi-Nan" agarwood; Aquilaria sinensis; 2-(2-phenylethyl)chromone; Neuroprotective activity

期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.7； 五年影响因子：1.8 ）

ISSN： 1874-3900

年卷期： 2024 年 60 卷

页码：

收录情况： SCI

摘要： Two unprecedented 2-(2-phenylethyl)chromone derivatives, (R)-2-[2-hydroxy-2-(3-hydroxy-4-methoxyphenyl) ethyl]chromone (1) and (R)-1-hydroxy-5-(4-hydroxyphenyl)-1-phenylpentane-3-one (2), with one known compound were isolated from cultivated "Qi-Nan" agarwood of Aquilaria sinensis. Their structures were elucidated by analysis of 1D and 2D NMR as well as HRESIMS. TDDFT-ECD calculation was used to determine the absolute configuration. At 50 mu M, compounds 1 and 3 exhibited significant neuroprotective effect, enhancing the cell vitality of human neuroblastoma SH-SY5Y cells induced by H2O2 to 73.24 +/- 0.43% and 74.71 +/- 5.24%, respectively.

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