Role of Metabolomics and Metagenomics in the Replacement of the High-Concentrate Diet with a High-Fiber Diet for Growing Yushan Pigs

文献类型： 外文期刊

第一作者： Xie, Min

作者： Xie, Min;Fei, Dan;Guang, Yelan;Xu, Jun;Zhou, Yaomin;Xue, Fuguang;Xu, Jun

作者机构：

关键词： energy; dietary fiber; growing swine; growth performance; fatty acids composition

期刊名称：ANIMALS （ 影响因子：2.7； 五年影响因子：3.2 ）

ISSN： 2076-2615

年卷期： 2024 年 14 卷 19 期

页码：

收录情况： SCI

摘要： Simple Summary: The objective of this study was to investigate the regulatory effects of replacing a high-concentrate diet with a high-fiber content feed, which consists of wheat bran, rice bran, and corn bran, on the productive performance, meat quality, and fat acid composition. Our findings showed that increasing dietary fiber content significantly increased average daily feed intake (ADFI), up-regulated carbohydrate metabolism-related metabolites, proliferated abundances of fiber-degradable microbial communities, such as Lactobacillus and Bifidobacterium, and significantly down-regulated lipid metabolism and cofactors and vitamin metabolism. Our findings indicated that higher dietary fiber content significantly reduced dietary energy provision, effectively decreased the backfat and abdominal fat content of Yushan pigs through proliferating intestinal fiber-degradable bacteria, and up-regulating the hepatic lipolysis-related gene expression. This finding may provide an altered method for rearing domestic Chinese pigs. The objective of this study was to investigate the regulatory effects of a high-fiber content feed on the productive performance, meat quality, and fat acid composition. A total of 18 120-day-old Yushan pigs with similar initial body weight were randomly allotted into high-concentrate diet (high energy, HE) and high-fiber diet (low energy, LE) treatments for the determination of regulatory effects on productive performance, meat quality, and fatty acid content. Further, blood metabolomic, gut microbiota, and liver energy-related gene expression measurements were used to investigate the underlying mechanisms. Results showed that the LE treatment significantly increased ADFI while decreasing carcass weight, fat percentage, and IMF. Metabolomic results showed that the high-fiber treatment significantly down-regulated metabolites that participated in lipid metabolism such as cyclic ADP-ribose and hippuric acid, while up-regulated metabolites were mainly enriched in nitrogen metabolism such as DL-arginine and propionylcarnitine (p < 0.05). Microbial results showed relative abundances of Lactobacillus and Bifidobacterium are significantly proliferated in the high-fiber feeding treatments (p < 0.05). Transcriptomic results showed that genes mainly enriched into the lipid metabolism are significantly up-regulated under the high-fiber dietary treatment (p < 0.05). Conclusion: higher dietary fiber significantly reduced dietary energy provision, effectively decreased the backfat and abdominal fat content of Yushan pigs through proliferating intestinal fiber-degradable bacteria, and up-regulating the hepatic lipolysis-related gene expression.

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