Thermo-responsive liposome nano-vesicles for co-delivery of emamectin benzoate and nitenpyram with synergistic pest control

文献类型： 外文期刊

第一作者： Du, Qian

作者： Du, Qian;Ding, Xi-Quan;Gao, Fei;Cui, Bo;Wang, Ting -Yu;Chen, Fang -Yuan;Chen, Long;Chen, Hong-Yan;Cui, Hai-Xin;Wang, Yan;Zeng, Zhang-Hua

作者机构：

关键词： Co -delivery; Liposome nano -vesicle; Thermo -responsive; Synergistic effect; Emamectin benzoate; Nitenpyram

期刊名称：CHEMICAL ENGINEERING JOURNAL （ 影响因子：15.1； 五年影响因子：14.3 ）

ISSN： 1385-8947

年卷期： 2024 年 479 卷

页码：

收录情况： SCI

摘要： The conventional pesticide formulations often suffer from low utilization rates and trigger the development of resistance, leading to significant resource waste and ecological damage. A promising solution to these issues lies in the design of intelligent, nanotechnology-based systems for controlled-release and co-delivery of pesticides. A multi-compartment liposome nano-vesicle (Co-EM-Lip) that simultaneously carries emamectin benzoate (EB) and nitenpyram (Nit) has been developed, using a eutectic mixture (EM) of fatty acids as a temperature-sensitive "switch". This Co-EM-Lip system successfully enabled the co-delivery of two pesticides with differing water solubility and insecticidal pathways, along with a thermo-responsive controlled release. The effectiveness of CoEM-Lip against Plutella xylostella was approximately 4.4 times higher at 35 degrees C than at 15 degrees C, which is attributable to high temperature-triggered rapid release properties. Importantly, EB and Nit within Co-EM-Lip demonstrated synergistic biological effects against various pests. Additionally, Co-EM-Lip showed less toxicity to zebrafish. This research thus introduces a novel strategy to devise smart, controlled-release and co-delivery pesticide systems aimed at enhancing pesticide efficiency, delaying pest resistance, and minimizing environmental harm and impact on non-target organisms.

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