Inactivated Recombinant Rabies Virus Displaying the Nipah Virus Envelope Glycoproteins Induces Systemic Immune Responses in Mice

文献类型： 外文期刊

第一作者： Li, Zhengrong

作者： Li, Zhengrong;Zhu, Yanting;Jin, Hongli;Yang, Songtao;Xia, Xianzhu;Cong, Yanlong;Yan, Feihu;Jin, Hongli;Wang, Qi;Zhao, Yongkun;Feng, Na;Wang, Tiecheng;Li, Nan;Yang, Songtao;Xia, Xianzhu

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关键词： Nipah virus; envelope glycoproteins; recombinant rabies virus; immune response; vaccine

期刊名称：VACCINES （ 影响因子：7.8； 五年影响因子：7.4 ）

ISSN：

年卷期： 2023 年 11 卷 12 期

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收录情况： SCI

摘要： Nipah virus (NiV) causes severe, lethal encephalitis in humans and pigs. However, there is no licensed vaccine available to prevent NiV infection. In this study, we used the reverse genetic system based on the attenuated rabies virus strain SRV9 to construct two recombinant viruses, rSRV9-NiV-F and rSRV9-NiV-G, which displayed the NiV envelope glycoproteins F and G, respectively. Following three immunizations in BALB/c mice, the inactivated rSRV9-NiV-F and rSRV9-NiV-G alone or in combination, mixed with the adjuvants ISA 201 VG and poly (I:C), were able to induce the antigen-specific cellular and Th1-biased humoral immune responses. The specific antibodies against rSRV9-NiV-F and rSRV9-NiV-G had reactivity with two constructed bacterial-like particles displaying the F and G antigens of NiV. These data demonstrate that rSRV9-NiV-F or rSRV9-NiV-G has the potential to be developed into a promising vaccine candidate against NiV infection.

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