Enhancing Animal Disease Resistance, Production Efficiency, and Welfare through Precise Genome Editing

文献类型： 外文期刊

第一作者： Liu, Zhiguo

作者： Liu, Zhiguo;Wu, Tianwen;Xiang, Guangming;Wang, Hui;Wang, Bingyuan;Mu, Yulian;Li, Kui;Feng, Zheng;Li, Kui

作者机构：

关键词： livestock animals; genome editing; precision breeding; disease resistance; regulatory system

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：6.208； 五年影响因子：6.628 ）

ISSN：

年卷期： 2022 年 23 卷 13 期

页码：

收录情况： SCI

摘要： The major goal of animal breeding is the genetic enhancement of economic traits. The CRISPR/Cas system, which includes nuclease-mediated and base editor mediated genome editing tools, provides an unprecedented approach to modify the mammalian genome. Thus, farm animal genetic engineering and genetic manipulation have been fundamentally revolutionized. Agricultural animals with traits of interest can be obtained in just one generation (and without long time selection). Here, we reviewed the advancements of the CRISPR (Clustered regularly interspaced short palindromic repeats)/Cas (CRISPR associated proteins) genome editing tools and their applications in animal breeding, especially in improving disease resistance, production performance, and animal welfare. Additionally, we covered the regulations on genome-edited animals (GEAs) and ways to accelerate their use. Recommendations for how to produce GEAs were also discussed. Despite the current challenges, we believe that genome editing breeding and GEAs will be available in the near future.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序