Engineering a Tumor-Acidity-Responsive PEG-Sheddable Nanoassembly for Combating Drug Resistance
文献类型： 外文期刊
第一作者： Xie, Jin
作者： Xie, Jin;Xie, Jin;Ouyang, Jun;Xie, Jin;Zhou, Mengxue;Ren, Hongyu;Dou, Rui;Zhang, Jiayu;Hu, Yi;Chen, Jun;Xie, Jin;Zhou, Mengxue;Ren, Hongyu;Dou, Rui;Zhang, Jiayu;Hu, Yi;Chen, Jun;Zhou, Mengxue;Hu, Yi
作者机构：
关键词： core-crosslinked micellar nanoassembly; co-delivery; drug resistance; nanomedicine; tumor-acidity-responsive
期刊名称：MACROMOLECULAR CHEMISTRY AND PHYSICS （ 影响因子：2.7； 五年影响因子：2.5 ）
ISSN： 1022-1352
年卷期： 2025 年 226 卷 13 期
页码：
收录情况： SCI
摘要： This study presents a simple strategy to develop a tumor-acidity responsive core-crosslinked micellar nanoassembly capable of delivering multiple drugs to combat drug resistance. Paclitaxel (PTX) nanocrystals are prepared using D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS) as an emulsifier and cross-linked with poly(beta-cyclodextrin) (PCD) to form the core. An acid-labile prodrug, poly(ethylene glycol)-doxorubicin (mPEG-DOX), is utilized as the shell, forming a core-shell nanoassembly (CSNA) via supramolecular interactions. The CSNA demonstrated high stability in aqueous and serum environments, with triggered shell-detachment in response to tumor acidity. The nanomedicine exhibited superior inhibition of drug-resistant cancer cell line MCF-7/ADR compared to DOX or PTX alone, offering potential to overcome drug resistance in chemotherapy.
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