Guanylate-binding protein 1 inhibits inflammatory factors produced by H5N1 virus through Its GTPase activity

文献类型： 外文期刊

第一作者： Jiang, Yanping

作者： Jiang, Yanping;Jia, Shuo;Li, Jiaxuan;Cui, Wen;Tang, Lijie;Jiang, Yanping;Cai, Limeng;Jia, Shuo;Xie, Weichun;Wang, Xueying;Li, Jiaxuan;Cui, Wen;Tang, Lijie;Li, Guiwei;Xia, Xianzhu

作者机构：

关键词： influenza A virus; GBP1; inflammatory cytokine; key action site; innate immune response

期刊名称：POULTRY SCIENCE （ 影响因子：4.4； 五年影响因子：4.4 ）

ISSN： 0032-5791

年卷期： 2024 年 103 卷 7 期

页码：

收录情况： SCI

摘要： The combination of inflammatory facof the main causes of death in host animals. Studies binding protein 1 (guanylate-binding protein 1, gGBP1) can downregulate cytokine production induced by the influenza virus. Therefore, exploring the innate immune defense mechanism of GBP1 in the proimplications for understanding the pathogenic mechanism, disease prevention, and the control of influenza A virus infections. We found that, in addition to inhibiting the early replication of influenza virus, gGBP1 also inhibited the production of CCL2 and CXCL10 cytokines induced by the influenza virus as well as the proliferation of mononuclear macrophages induced by these cytokines. These findings further confirmed that gGBP1 inhibited the production of cytokines through its GTPase activity and cell proliferation through its C-terminal a-helix structure. This study revealed the effect of gGBP1 on the production of cellular inflammatory factors during influenza virus infection and determined the key amino acid residues that assist in the inhibitory processes mediated by gGBP1.

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