A new fluorescent probe for hydrogen sulfide based on naphthalimide derivatives and its biological application

文献类型： 外文期刊

第一作者： Shi, Jiacheng

作者： Shi, Jiacheng;Liu, Lin;Guo, Fengqi;Shi, Jiacheng;Zhang, Di;Li, Man;Liu, Lin;Wang, Tieliang;Wu, Xujin;Wang, Yanliang

作者机构：

关键词： H2S; Fluorescence; Naphthalimide; Bioimaging

期刊名称：INORGANIC CHEMISTRY COMMUNICATIONS （ 影响因子：3.428； 五年影响因子：2.553 ）

ISSN： 1387-7003

年卷期： 2022 年 146 卷

页码：

收录情况： SCI

摘要： As a signal transduction molecule in organism, H2S plays an important role in many physiological processes. In this paper, a novel H2S fluorescent probe SBD was designed based on 1,8-naphthalimide and dini-trobenzenesulfonyl group. In DMSO-PBS solution, probe SBD could recognize H2S and change the color of so-lution from yellow to pink, realizing the naked eye recognition for H2S. In addition, probe SBD displayed high fluorescence enhancement rate (45-fold), good selectivity, strong anti-interference ability and the detection limit was as low as 152 nM. Most importantly, probe SBD showed very low cytotoxicity and had been successfully applied to image exogenous H2S in living cells.

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