Article Photoregulatory protein kinases fine-tune plant photomorphogenesis by directing a bifunctional phospho-code on HY5 in Arabidopsis

文献类型： 外文期刊

第一作者： Zhang, Nan

作者： Zhang, Nan;Wei, Chuang-Qi;Xu, Da-Jin;Zhao, Ya-Chao;Sun, Ying;Zhang, Sheng-Wei;Wei, Chuang-Qi;Wang, Zhi-Yong;Wei, Chuang-Qi;Deng, Zhi-Ping;Ai, Lian-Feng

作者机构：

期刊名称：DEVELOPMENTAL CELL （ 影响因子：10.7； 五年影响因子：11.5 ）

ISSN： 1534-5807

年卷期： 2024 年 59 卷 13 期

页码：

收录情况： SCI

摘要： Photomorphogenesis is a light-dependent plant growth and development program. As the core regulator of photomorphogenesis, ELONGATED HYPOCOTYL 5 (HY5) is affected by dynamic changes in its transcriptional activity and protein stability; however, little is known about the mediators of these processes. Here, we identified PHOTOREGULATORY PROTEIN KINASE 1 (PPK1), which interacts with and phosphorylates HY5 in Arabidopsis, as one such mediator. The phosphorylation of HY5 by PPK1 is essential to establish high-affinity binding with B-BOX PROTEIN 24 (BBX24) and CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1), which inhibit the transcriptional activity and promote the degradation of HY5, respectively. As such, PPKs regulate not only the binding of HY5 to its target genes under light conditions but also HY5 degradation when plants are transferred from light to dark. Our data identify a PPK-mediated phospho-code on HY5 that integrates the molecular mechanisms underlying the regulation of HY5 to precisely control plant photomorphogenesis.

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