Biointerfacial giant capsules with high paclitaxel loading and magnetic targeting for breast tumor therapy

文献类型： 外文期刊

第一作者： Tan, Xin

作者： Tan, Xin;Zhang, Yu;Ge, Liqin;Li, Shiming;Liu, Ling;Sheng, Renwang;Zhang, Qianli;Li, Chunyang

作者机构：

关键词： Paclitaxel; Biointerfacial giant microcapsules; Layer-by-layer self-assembly technique; Hydrophobic drug delivery systems; Breast tumor therapy

期刊名称：JOURNAL OF COLLOID AND INTERFACE SCIENCE （ 影响因子：9.9； 五年影响因子：8.4 ）

ISSN： 0021-9797

年卷期： 2023 年 633 卷

页码：

收录情况： SCI

摘要： High drug loading, targeted delivery, prolonged drug release, and low systemic toxicity are effective weapons for hydrophobic drug delivery systems to solve serious concerns in poor water-solubility and toxicity of paclitaxel (PTX). Herein, we reported that biointerfacial giant multilayer microcapsules (BGMs) with the feature of high-density drug loading and high-efficiency magnetic delivery were fabri-cated templated by PTX-liposome-microbubble complex using the layer-by-layer self-assembly (LbL) technique. The drug loading capacity of BGMs was improved by optimizing the structure of microbubbles and capsules to increase the PTX-contained layers, and the resultant BGMs exhibited high drug loading content (50.56 +/- 0.09 %) and sustained drug release properties. The BGMs with an average diameter of 74.1 +/- 12.1 lm and an average thickness of 275.5 +/- 48.4 nm contained abundant magnetic nanoparticles (MNPs) in their cavity, which endowed these capsules with outstanding magnetic properties and fast magnetophoretic velocity in the blood (-0.3 mm/s, pB = 1 T/mm). Moreover, both in vitro and in vivo studies demonstrated that the biocompatible PTX-loaded magnetic BGMs (Capsule@PLMPPL) caused notable death (71.3 +/- 2.9 %) of 4 T1 breast cancer cells through PTX diffusion, capsules degradation, and subsequent endocytosis by cancer cells, and ultimately effectively inhibited tumor growth. In gen-eral, the developed BGM with good deformability and degradation was the first reported giant polyelec-trolyte capsule to be used in tumor therapy, which could notably improve the therapeutic efficacy of PTX while reducing its side effects. (c) 2022 Elsevier Inc. All rights reserved.

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