Integrated Fiber-Optic SPR Sensor with Cyclone Sampling for Rapid On-Site Bioaerosol Pathogen Detection

文献类型： 外文期刊

第一作者： Jiang, Shiyu

作者： Jiang, Shiyu;Qian, Siyu;Guo, Ying;Geng, Yikai;Guo, Baoming;Yang, Ruihua;Chen, Xuefeng;Liu, Shengchun;Jiang, Shiyu;Chen, Zhaoliang;Guo, Zhendong

作者机构：

关键词： surface plasmon resonance; AuNPs; bioaerosolviruses detection; cyclone sampling; fiber-opticsensor

期刊名称：ACS SENSORS （ 影响因子：9.1； 五年影响因子：8.9 ）

ISSN： 2379-3694

年卷期： 2025 年 10 卷 8 期

页码：

收录情况： SCI

摘要： On-site infectious bioaerosol detection is crucial for preventing various adverse health effects. A bioaerosol enrichment and detection system (BEDS) was developed by integrating a fiber-optic surface plasmon resonance (SPR) sensor with a cyclone air sampler for rapid on-site detection of aerosol-borne viruses. The fiber-optic SPR sensor incorporates a sandwich immunoassay strategy with gold nanoparticles introduced to further enhance the detection signal. In the cyclone sampler, infectious bioaerosols are converted to hydrosol through centrifugal and shear forces. The BEDS realizes sensitive H3N2 virus detection with a limit of detection down to 297.3 TCID50/mLbuffer. A bioaerosol collection efficiency of 97.9% was achieved. It accurately identifies mixed-aerosol H3N2 and H1N1 viruses, analyzes exhaled pathogen concentrations from infected mice, and monitors disease progression. This system offers an on-site, preprocessing-free approach for early bioaerosol monitoring and epidemiological research.

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