MCT1 plays crucial roles in conidiation, lactate metabolism and pathogenicity in Colletotrichum gloeosporioides

文献类型： 外文期刊

第一作者： Zhao, Xuanzhu

作者： Zhao, Xuanzhu;Wang, Na;Ji, Zhirui;Zhou, Zongshan;Zhang, Junxiang

作者机构：

关键词： Anthracnose; apple; Colletotrichum gloeosporioides; conidia; Glomerella; monocarboxylate transporter

期刊名称：CANADIAN JOURNAL OF PLANT PATHOLOGY （ 影响因子：2.0； 五年影响因子：2.0 ）

ISSN： 0706-0661

年卷期： 2023 年 45 卷 2 期

页码：

收录情况： SCI

摘要： Monocarboxylate transporters (MCTs) play vital roles in carbon source assimilation, drug resistance and virulence. However, the underlying function of MCTs in fungal pathogenesis and development has not been investigated in detail. In this study, we identified and characterized the monocarboxylate transporter gene MCT1 of Colletotrichum gloeosporioides, which is the causal agent of Glomerella leaf spot of apple. Mct1 is localized to the mitochondria and may mediate the uptake of lactate to the cell. However, MCT1 was constitutively expressed but showed an enhanced expression level in response to the presence of the extracellular lactate. Our results indicate that Mct1 plays a role in the metabolism of lactate. More importantly, the Delta mct1 mutant showed significantly poor conidiation and a defect in host infection. Taken together, our studies provide evidence for Mct1 as a mitochondrial transmembrane protein mediating conidiation, the metabolism of lactate, and the pathogenicity of C. gloeosporioides.

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