Pharmacokinetics and tissue residues of moroxydine hydrochloride in gibel carp, Carassius gibelio after oral administration

文献类型： 外文期刊

第一作者： Liu, W.

作者： Liu, W.;Xu, J.;Zhou, Y.;Chen, J.;Ma, J.;Zeng, L.

作者机构：

期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.786； 五年影响因子：1.7 ）

ISSN： 0140-7783

年卷期： 2016 年 39 卷 4 期

页码：

收录情况： SCI

摘要： The pharmacokinetics and tissue residues of moroxydine hydrochloride were studied in gibel carp at water temperature of 15 and 25 degrees C. Samples (blood, skin, muscle, liver, and kidney) were collected over 10 days after the treatment and analyzed by high-performance liquid chromatography with an ultraviolet detector. The results indicated that the influence of water temperature on the metabolism of the drug was significant. The plasma concentration-time data of moroxydine hydrochloride conformed to single-compartment open model at the two water temperatures. There were higher absorption rate (t(1/2ka)) and longer elimination half-lives (t(1/2ke)) at 15 degrees C (4.29 and 15.87 h, respectively) compared with those at 25 degrees C (3.02 and 4.22 h, respectively). The maximum plasma concentration (C-max) and the time-point of maximum plasma concentration (T-p) were 2.98 mu g/mL and 10.35 h at 15 degrees C and 3.12 mu g/mL and 4.03 h at 25 degrees C, respectively. The distribution volume (V-d/F) of moroxydine hydrochloride was estimated to be 4.55 L/ kg at 15 degrees C and 2.89 L/kg at 25 degrees C. The total body clearance (CLb) of moroxydine hydrochloride was determined to be 0.25 and 0.49 L/(h.kg) at 15 degrees C and 25 degrees C, respectively; the areas under the concentration-time curve were 75.89 mu g.h/mL at 15 degrees C and 42.33 mu g.h/mL at 25 degrees C. The depletion of moroxydine hydrochloride in gibel carp was slower with a longer half-life period, especially at lower water temperature that was tested.

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