The Inhibition on MDFIC and PI3K/AKT Pathway Caused by miR-146b-3p Triggers Suppression of Myoblast Proliferation and Differentiation and Promotion of Apoptosis

文献类型： 外文期刊

第一作者： Huang, Weiling

作者： Huang, Weiling;Guo, Lijin;Zhao, Minxing;Zhang, Dexiang;Xu, Haiping;Nie, Qinghua;Huang, Weiling;Guo, Lijin;Zhao, Minxing;Zhang, Dexiang;Xu, Haiping;Nie, Qinghua;Huang, Weiling;Guo, Lijin;Zhao, Minxing;Zhang, Dexiang;Xu, Haiping;Nie, Qinghua

作者机构：

关键词： miR-146b-3p; AKT1; myoblast; proliferation; differentiation; apoptosis

期刊名称：CELLS （ 影响因子：6.6； 五年影响因子：6.663 ）

ISSN：

年卷期： 2019 年 8 卷 7 期

页码：

收录情况： SCI

摘要： Accumulating studies report that microRNAs (miRNAs) are actively involved in skeletal myogenesis. Previously, our study revealed that miR-146b-3p was related to the growth of skeletal muscle. Here, we further report that miR-146b-3p is essential for the proliferation, differentiation, and apoptosis of chicken myoblast. Elevated expression of miR-146b-3p can dramatically suppress proliferation and differentiation, and facilitate apoptosis of chicken myoblast. Besides, we identified two target genes of miR-146b-3p, AKT1 and MDFIC, and found that miR-146b-3p can inhibit the PI3K/AKT pathway. Our study also showed that both AKT1 and MDFIC can promote the proliferation and differentiation while inhibit the apoptosis of myoblast in chicken. Overall, our results demonstrate that miR-146b-3p, directly suppressing PI3K/AKT pathway and MDFIC, acts in the proliferation, differentiation, and apoptosis of myoblast in chicken.

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