Comparisons of lung and gluteus transcriptome profiles between yaks at different ages

文献类型： 外文期刊

第一作者： Xin, Jin-Wei

作者： Xin, Jin-Wei;Zhang, Cheng-Fu;Zhang, Qiang;Zhu, Yong;Cao, Han-Wen;Ji, Qiu-Mei;Xin, Jin-Wei;Zhang, Cheng-Fu;Zhang, Qiang;Zhu, Yong;Cao, Han-Wen;Ji, Qiu-Mei;Chai, Zhi-Xin;Zhong, Jin-Cheng;Chai, Zhi-Xin;Zhong, Jin-Cheng

作者机构：

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2019 年 9 卷

页码：

收录情况： SCI

摘要： The yak, Bos grunniens, is the only large mammal in the Qinghai-Tibet Plateau and has been bred to provide meat, milk, and transportation. Previous studies indicate that the immune system contributes to the yak's adaptation to high-altitude environments. In order to further investigate changes in immune function during yak development, we compared the transcriptome profiles of gluteus and lung tissues among yaks at 6, 30, 60, and 90 months of age. Analyses of significantly differentially expressed genes (DEGs) in lung tissues revealed that immune function was more activated at 6-months and less activated at 90-months than in the 30 and 60-month-old animals. DEG exploration in gluteal tissues revealed that immune functions were more highly activated at both 6 and 90-months, compared with 30 and 60-months. Immune system activation in the muscle and lung tissues of 30-month-old yaks may increase their resistance to infections, while decreased may be due to aging. Furthermore, the higher immune activation status in the gluteal tissues in 90-month-old yaks could be due to muscle injury and subsequent regeneration, which is supported by the fact that 5 unigenes related with muscle injury and 3 related to muscle regeneration displayed greater expression levels at 90-months than at 30 and 60-months. Overall, the present study highlights the important role of the immune system in yak development, which will facilitate future investigations.

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