Influence of Human Serum Albumin Glycation on the Binding Affinities for Natural Flavonoids

文献类型： 外文期刊

第一作者： Xie, Yixi

作者： Xie, Yixi;Liu, Liangliang;Liu, Yi;Xiao, Aiping;Mei, Shiyong

作者机构：

关键词： Diabetes; Flavonoids; Fluorescence spectra; Glycation; Human serum albumin

期刊名称：OPEN CHEMISTRY （ 影响因子：1.554； 五年影响因子：1.8 ）

ISSN： 2391-5420

年卷期： 2019 年 17 卷 1 期

页码：

收录情况： SCI

摘要： Increasing the degree of glycation in diabetes could affect the ability of plasma proteins in binding to small molecules and active compounds. In this study, the influence of glycation of Human serum albumin (HSA) on the binding affinities for six dietary flavonoids was investigated by fluorescence spectra. Glycated HSA was prepared through incubation with glucose and characterized by several methods to confirm the glycation. It was found that the level of glycation increased with the increasing incubation time. The glycation of HSA increased the binding affinities for flavonoids by 1.40 to 48.42 times, which indicates that modifications caused by the glycation may have different influences on the interactions of flavonoids with HSA at separate binding sites on this protein. These results are valuable for understanding the influence of diabetes on the metabolism of flavonoids and other bioactive small molecules in human body.

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