Mir-152 Regulates 3T3-L1 Preadipocyte Proliferation and Differentiation

文献类型： 外文期刊

第一作者： Fan, Yuan

作者： Fan, Yuan;Gan, Mailin;Tan, Ya;Chen, Lei;Shen, Linyuan;Niu, Lili;Tang, Guoqing;Jiang, Yanzhi;Li, Xuewei;Zhang, Shunhua;Bai, Lin;Zhu, Li;Fan, Yuan;Gan, Mailin;Tan, Ya;Chen, Lei;Shen, Linyuan;Niu, Lili;Tang, Guoqing;Jiang, Yanzhi;Li, Xuewei;Zhang, Shunhua;Bai, Lin;Zhu, Li;Liu, Yihui;Tan, Ya

作者机构：

关键词： miR-152; LPL; 3T3-L1 preadipocyte; lipoprotein lipase; obesity

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN：

年卷期： 2019 年 24 卷 18 期

页码：

收录情况： SCI

摘要： Adipogenesis is a complex biological process and the main cause of obesity. Recently, microRNAs (miRNAs), a class of small endogenous non-coding RNAs, have been proven to play an important role in adipogenesis by the post-transcriptional regulation of target genes. In this current study, we observed an increment of miR-152 expression during the process of 3T3-L1 cell audiogenic differentiation. A functional analysis indicated that the overexpression of miR-152 inhibited pre-adipocyte proliferation and suppressed the expression of some cell cycle-related genes. Moreover, the overexpression of miR-152 promoted lipid accumulation in 3T3-L1 preadipocytes accompanied by increase of the expression of some pro-audiogenic genes. Additionally, a dual-luciferase reporter assay demonstrated lipoprotein lipase (LPL) was a direct target gene of miR-152 during preadipocyte differentiation. Further analysis showed that miR-152 was positively correlated with adipogenesis and intramuscular fat formation in vivo. Taken together, our findings suggest that miR-152 could suppress 3T3-L1 preadipocyte proliferation, whereas it could promote 3T3-L1 preadipocyte differentiation by negatively regulating LPL. The findings indicate that miR-152 might have a therapeutic significance for obesity and obesity-related metabolic syndrome.

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