Anti-inflammatory potency of Locusta migratoria manilensis cyclopeptides in mast cells and macrophages

文献类型： 外文期刊

第一作者： Liu, Jie

作者： Liu, Jie;Wang, Huailing;Liu, Zhigang;Liu, Jie;Wang, Huailing;Luo, Qiang;Cao, Hui;Liu, Xiaoyu;Yang, Pingchang;Liu, Zhigang;Wang, Guangjun;Zhang, Zehuang

作者机构：

期刊名称：RSC ADVANCES （ 影响因子：3.361； 五年影响因子：3.39 ）

ISSN：

年卷期： 2019 年 9 卷 54 期

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收录情况： SCI

摘要： Locusts are esteemed as a traditional Chinese medicine, as well as tonic foods in Asian countries. While searching for natural anti-inflammatory agents in natural products, we isolated four novel locust cyclopeptides (LCPs) and the results show that [cyclo-(Trp-Leu-His-Thr)]similar to LCP-3 has potent anti-inflammatory potency in RAW264.7 and HMC-1 cells under LPS (lipopolysaccharide) stimuli. Furthermore, mechanistic studies show that LCP-3 attenuates pro-inflammatory cytokine (TNF-alpha, IL-6, IL-1 beta, NO and PGE2) expression. Moreover, LCP-3 attenuates inflammatory damage associated with the direct inhibition of iNOS and COX-2 expression. LCP-3 also regulates the MAPK, PI3K/AKT and NF-kappa B pathways to attenuate LPS-induced damage. Of note, our study first reports the anti-inflammatory potency of LCPs and elucidates their underlying molecular mechanisms.

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