Geminivirus C4 antagonizes the HIR1-mediated hypersensitive response by inhibiting the HIR1 self-interaction and promoting degradation of the protein

文献类型： 外文期刊

第一作者： Mei, Yuzhen

作者： Mei, Yuzhen;Ma, Zhonghua;Wang, Yaqin;Zhou, Xueping;Zhou, Xueping

作者机构：

关键词： C4; degradation; geminivirus; hypersensitive response; hypersensitive induced reaction 1; leucine-rich repeat protein 1; tomato leaf curl Yunnan virus

期刊名称：NEW PHYTOLOGIST （ 影响因子：10.151； 五年影响因子：10.475 ）

ISSN： 0028-646X

年卷期： 2020 年 225 卷 3 期

页码：

收录情况： SCI

摘要： Tomato leaf curl Yunnan virus (TLCYnV)-encoded C4 protein induces the upregulation of the hypersensitive induced reaction 1 (HIR1) gene but interferes with the HIR1-mediated hypersensitive response (HR). HIR1 self-interaction is essential for the HIR1-induced HR. TLCYnV C4 impairs the HIR1 self-interaction and concomitantly increases the amount of Leucine-Rich Repeat protein 1 (LRR1), a modulator of HIR1, which binds to HIR1. LRR1 promotes the degradation of HIR1, compromising the HIR1-mediated HR. This study provides new insights into the mechanisms employed by a viral protein to counter host resistance through the cooption of the host regulatory system.

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