文献类型： 外文期刊
第一作者： Tang, Guangfei
作者： Tang, Guangfei;Xia, Haoxue;Huang, Yufei;Guo, Yuanwen;Liu, Wende;Huang, Yufei;Chen, Yun;Ma, Zhonghua
作者机构：
期刊名称：GENOME BIOLOGY （ 影响因子：12.3； 五年影响因子：17.4 ）
ISSN： 1474-760X
年卷期： 2024 年 25 卷 1 期
页码：
收录情况： SCI
摘要： BackgroundBromo-adjacent homology-plant homeodomain domain containing protein 1 (BP1) is a reader of histone post-translational modifications in fungi. BP1 recognizes trimethylation of lysine 27 in histone H3 (H3K27me3), an epigenetic hallmark of gene silencing. However, whether and how BP1 participates in transcriptional repression remains poorly understood.ResultsWe report that BP1 forms phase-separated liquid condensates to modulate its biological function in Fusarium graminearum. Deletion assays reveal that intrinsically disordered region 2 (IDR2) of BP1 mediates its liquid-liquid phase separation. The phase separation of BP1 is indispensable for its interaction with suppressor of Zeste 12, a component of polycomb repressive complex 2. Furthermore, IDR2 deletion abolishes BP1-H3K27me3 binding and alleviates the transcriptional repression of secondary metabolism-related genes, especially deoxynivalenol mycotoxin biosynthesis genes.ConclusionsBP1 maintains transcriptional repression by forming liquid-liquid phase-separated condensates, expanding our understanding of the relationship between post-translational modifications and liquid-liquid phase separation.
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