Identification of the JY-1 in sika deer and its effects on granulosa cells cultured in vitro

文献类型： 外文期刊

第一作者： Chen, Xiumin

作者： Chen, Xiumin;Xing, Mingjie;Yang, Yifeng;Chen, Min;Chang, Tong;Xu, Baozeng;Wei, Haijun;Chen, Xiumin;Xing, Mingjie;Yang, Yifeng;Chen, Min;Chang, Tong;Xu, Baozeng;Wei, Haijun

作者机构：

关键词： apoptosis; cell cycle; JY-1

期刊名称：REPRODUCTION IN DOMESTIC ANIMALS （ 影响因子：2.005； 五年影响因子：2.154 ）

ISSN： 0936-6768

年卷期： 2019 年 54 卷 11 期

页码：

收录情况： SCI

摘要： The oocyte-specific protein JY-1 was reported as an important regulator of both function of ovarian granulosa cells and early embryogenesis in cattle. Here, we found that the transcripts of JY-1 were also present in sika deer granulosa cells (GCs) through in situ hybridization and qRT-PCR. The complete sika deer JY-1 coding sequence was identified, which had three exons separated by two introns. It was detected that JY-1 knockdown caused apoptosis and abnormal cell cycle progression in GCs of sika deer cultured in vitro. Taken together, these data suggest that JY-1 is involved in the regulation of proliferation in sika deer ovarian GCs.

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