Parental exposure to triphenyltin inhibits growth and disrupts thyroid function in zebrafish larvae
文献类型： 外文期刊
第一作者： Li, Ping
作者： Li, Ping;Li, Zhi-Hua;Li, Zhi-Hua;Zhong, Liqiao
作者机构：
关键词： Triphenyltin; Parental exposure; Thyroid system disruption; Growth inhibition; Zebrafish
期刊名称：CHEMOSPHERE （ 影响因子：7.086； 五年影响因子：6.956 ）
ISSN： 0045-6535
年卷期： 2020 年 240 卷
页码：
收录情况： SCI
摘要： Triphenyltin (TPT) is widely used and commonly found in a water environment, so its effects on aquatic systems are of great concern. This study aimed to reveal the effects of chronic parental exposure of TPT on thyroid disruption and growth inhibition in zebrafish. Adult zebrafish (FO generation) were exposed to environmentally relevant concentrations (1, 10, and 100 ng/L) of TPT for 60 days, and the larvae (F1 generation) were tested without TPT treatment. Results demonstrated that parental exposure to TPT disrupts thyroid function in zebrafish offspring: serum thyroxine (T4) significantly decreased, while serum 3,5,3'-triiodothyronine (T3) increased, and several genes involved in the hypothalamic-pituitary -thyroid (HPT) axis were down-regulated. In addition, we observed developmental abnormalities in the larvae, demonstrated by a significantly altered hatching rate, malformation rate, body length, heart rate, and survival rate, as well as down-regulation of genes involved in the growth hormone/insulin-like growth factor (GH/IGF) axis. Therefore, parental exposure to TPT induces toxicity in fish offspring through perturbation of the HPT and GH/IGF axes. (C) 2019 Elsevier Ltd. All rights reserved.
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