IDENTIFICATION OF TWO NOVEL SINGLE NUCLEOTIDE POLYMORPHISM SITES IN THE MYOSTATIN (MSTN) GENE AND THEIR ASSOCIATION WITH CARCASS TRAITS IN MEAT-TYPE RABBITS (ORYCTOLAGUS CUNICULUS)
文献类型： 外文期刊
第一作者： Yang, L. Q.
作者： Yang, L. Q.;Zhang, K.;Wu, Q. Y.;Zhang, M.;Li, J.;Lai, S. J.;Song, T. Z.
作者机构：
关键词： rabbit; myostatin gene; single nucleotide polymorphisms; carcass traits
期刊名称：WORLD RABBIT SCIENCE （ 影响因子：1.233； 五年影响因子：1.018 ）
ISSN： 1257-5011
年卷期： 2019 年 27 卷 4 期
页码：
收录情况： SCI
摘要： Two unknown single nucleotide polymorphism (SNP) sites In exons 1 (c.194C>I) and 2 (c.445T>A) of meat-type rabbit MSTN gene were Identified In the study. Our objective was to analyse the population genetics structure of the two novel SNP sites in 230 individuals from six breeds and their associations with carcass traits of rabbits. We found that live body weight (BW), cold carcass weight (CCW), reference carcass weight (RCW), CCW percentage (P-CCW) and RCW percentage (P-RCW) of the rabbits with the genotype CC at the c.194C>T of exon 1 or Mat the c.445T>A of exon 2 were significantly higher than those with other genotypes. Diplotype significantly affected BW, RCW, CCW, P-RCW (P<0.01) and P-CCW and P-CM (P<0.05). CC/AA was the advantageous diplotype for BW, RCW, CCW and P-CM, and TT/AA was the advantageous diplotype for P-CCW, and P-RCW. In contrast, TT/TT was the negative diplotype for BW, CCW, RCW, P-CCW, and P-RCW, and TT/AA was the negative diplotype for P-CM. The results suggest that the two new mutations of MSTN gene significantly affected BW, CCW, RCW, P-CCW and P-RCW of rabbits, and MSTN may be an Important candidate gene of carcass traits in meat-type rabbits.
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