Quinazoline-Containing Indole Alkaloids from the Marine-Derived Fungus Aspergillus sp. HNMF114

文献类型： 外文期刊

第一作者： Kong, Fan-Dong

作者： Kong, Fan-Dong;Ma, Qing-Yun;Xie, Qing-Yi;Chen, Jin-Ping;Li, Jiu-Hui;Zhou, Li-Man;Yuan, Jing-Zhe;Dai, Hao-Fu;Zhao, You-Xing;Zhang, Sheng-Liang;Zhou, Shuang-Qing;Huang, Xiao-Long;Hu, Zhong

作者机构：

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.05； 五年影响因子：4.603 ）

ISSN： 0163-3864

年卷期： 2019 年 82 卷 12 期

页码：

收录情况： SCI

摘要： Seven new quinazoline-containing indole alkaloids (17) named aspertoryadins A-G, along with nine known ones (8-16), were isolated from the marine -derived fungus Aspergillus sp. HNMF114 from the bivalve mollusk Sanguinolaria chinensis. The structures of the new compounds were elucidated from spectroscopic data, X-ray diffraction analysis, ECD spectra analysis, and ECD calculations. Compound 1 bears an aminosulfonyl group in the structure, which is rarely encountered in natural products. Compounds 6, 7, and 13 exhibited quorum sensing inhibitory activity against Chromobacterium violaceum CV026 with MIC values of 32, 32, and 16 mu g/well, respectively.

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