文献类型： 外文期刊
第一作者： Liu, Shou-Bai
作者： Liu, Shou-Bai;Cui, Zheng;Chen, Hui-Qin;Wang, Hao;Dong, Wen-Hua;Cai, Cai-Hong;Mei, Wen-Li;Dai, Hao-Fu
作者机构：
关键词： Heynea trijuga Roxburgh; Ergostane derivative; Cytotoxic activity
期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.861； 五年影响因子：2.572 ）
ISSN： 1478-6419
年卷期：
页码：
收录情况： SCI
摘要： During the course of searching for structurally interesting and bioactive compounds, a further chemical investigation of the leaves of Heynea trijuga Roxburgh was performed, which led to the isolation of a new ergostane derivative, named 3 beta, 4 beta, 20S-trihydroxyergosta-5, 24(28)-dien-16-one (1), together with five known sterides (3 beta, 23S)-ergosta-5, 24(28)-diene-3, 23-diol (2), ergosta-5, 24(28)-diene-3 beta-diol (3), stigmast-5-ene-3 beta, 7 alpha-diol (4), sitoindoside I (5) and stigmast-3 beta, 5 alpha, 6 beta-triol (6). The structure of the new compound was elucidated using a combination of 1 D, 2 D NMR techniques and HR-EI-MS analyses. All the compounds were evaluated for cytotoxic activity against tumor cell line BEL-7402 by MTT method.
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