Solid phase extraction technology combined with UPLC-MS/MS: a method for detecting 20 β-lactamase antibiotics traces in goat's milk

文献类型： 外文期刊

第一作者： Li, Ming

作者： Li, Ming;Wang, Zhaohua;Yan, Xiaohuan;Li, Songli;He, Xiwen;Liu, Wuyan;Li, Xiang;He, Xiwen;Liu, Wuyan;Yu, Qi;Sun, Shufang;Wang, Zhaohua

作者机构：

期刊名称：ANALYTICAL METHODS （ 影响因子：3.1； 五年影响因子：3.0 ）

ISSN： 1759-9660

年卷期： 2024 年 16 卷 19 期

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收录情况： SCI

摘要： We develop and validate a method for the rapid determination and identification of 20 beta-lactamase antibiotics traces in goat's milk by combining the solid phase extraction technology with ultra-high performance liquid chromatography-tandem mass spectrometry. Goat milk samples were extracted with acetonitrile twice. The supernatant was then extracted and cleaned by solid-phase extraction using divinylbenzene and N-vinylpyrrolidone copolymer. The method was validated, with limits of quantification (LOQs) of 0.3 mu g kg(-1), specificities of 1/3 LOQ, linearities (R-2) > 0.99, recoveries of 80-110%, repeatabilities <10.0%, and intermediate precisions <10.0%. The developed method was suitable for the routine analysis of beta-lactamase antibiotics residues in goat's milk and was used to test 76 goat milk samples produced in China.

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