An efficient synthesis of spiroacridinone derivatives from the facile reaction of isatins, dimedone, and 5-aminoindazole (6-aminoindazole or 5-aminoindole)
文献类型： 外文期刊
第一作者： Zhang, Wen-Ting
作者： Zhang, Wen-Ting;Sun, Jian;Zhu, Hong;Yue, Rui-Xue;Zhang, Yi;Niu, Fu-Xiang;Zhang, Wen-Ting;Rong, Liangce
作者机构：
期刊名称：JOURNAL OF HETEROCYCLIC CHEMISTRY （ 影响因子：2.193； 五年影响因子：1.645 ）
ISSN： 0022-152X
年卷期： 2020 年 57 卷 4 期
页码：
收录情况： SCI
摘要： We have developed a simple and facil protocol for the synthesis of tetrahydrospiro(indoline-3,11 '-pyrazolo[4,3-a]acridine)-2,10 '(7 ' H)-dione, tetrahydrospiro(indoline-3, 11 '-pyrazolo[3,4-a]acridine)-2,10 '(7 ' H)-dione, and tetrahydrospiro (indoline-3,11 '-pyrrolo[3,2-a]acridine)-2,10 '(7 ' H)-dione via PTSA center dot H2O-induced cyclization reaction from isatins, dimedone, and 5-aminoindazole (6-aminoindazole or 5-aminoindole) in mixed solvent (EtOH and CH3CN). In this research, 5-aminoindazole, 6-aminoindazole, and 5-aminoindole were effectively used to react with isatins and dimedone to give spiroacridinone derivatives. The advantages of this method are mild conditions, convenient manipulation, high yields, and a wide range of substrates.
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