Evaluation of protective efficacy of inactivated Mycoplasma synoviae vaccine with different adjuvants

文献类型： 外文期刊

第一作者： Gong, Xiaowei

作者： Gong, Xiaowei;Chen, Qiwei;Liu, Yongsheng;Zheng, Fuying;Ferguson-Noel, Naola;Stipkovits, Laszlo;Szathmary, Susan

作者机构：

关键词： Mycoplasma synoviae; Adjuvants; Subcutaneous immunization; Bacterin

期刊名称：VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY （ 影响因子：2.046； 五年影响因子：2.217 ）

ISSN： 0165-2427

年卷期： 2020 年 220 卷

页码：

收录情况： SCI

摘要： Mycoplasma synoviae (MS) is a poultry pathogen with a reported distribution throughout the world. Vaccination is utilized as an important component of MS control programs for MS infection. The aim of this study was to evaluate protection efficacy of an inactivated MS vaccine (MS bacterin) with different adjuvants in broilers against a Chinese field isolate (CHN-BZJ2-2015). Vaccination with adjuvants ISA 71 VG and chitosan, respectively, enhanced specific lymphocyte proliferation responses and upregulated the expression of IL-1 beta, IL-6, IL-2 and IFN-gamma prior to challenge. Furthermore, vaccination with adjuvant ISA 71 VG elicited the highest antibody titers, exhibited significantly lower air sac, foot pad and tracheal lesions than the other groups (P < 0.05), and decreased MS colonization. These results demonstrated that inactivated MS vaccine with ISA 71 VG is able to induce both cellular and humoral immune response in broilers and confers a high level of protection upon challenge, demonstrating a potential application in the field.

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