文献类型： 外文期刊
第一作者： Zhang, Shu
作者： Zhang, Shu;Lyu, Kaiyu;Liu, Huan;Han, Gang;Wu, Lidong;Xiao, Ming;Zhang, Yuqian;Li, Yang;Rathi, Brijesh
作者机构：
关键词： Neuromelanin-like nanoparticles; Amino acid; Fluorescence; Lead ions
期刊名称：ANALYTICA CHIMICA ACTA （ 影响因子：6.558； 五年影响因子：6.228 ）
ISSN： 0003-2670
年卷期： 2020 年 1105 卷
页码：
收录情况： SCI
摘要： Exposure to even very low concentration of Pb2+ can cause neurological and developmental disorders, and affects children more severely. Neuromelanin (NM) in the substantial nigra can trap endogenous and environmental toxins and immobilize them as stable adducts, thus protecting brain against toxicity. Until now, the structure and Pb2+-chelating ability of NM is still little understood. Here, we prepare a mimicking NM by amino acid and dopamine. The prepared NM has strong fluorescent and its fluorescence can be quenched by Pb2+. This study offers a novel way to synthetic NM and provides an effective method to detect Pb2+. (C) 2020 Elsevier B.V. All rights reserved.
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