Deep eutectic solvents for biocatalytic transformations: focused lipase-catalyzed organic reactions

文献类型： 外文期刊

第一作者： Tan, Jia-Neng

作者： Tan, Jia-Neng;Dou, Yuqing

作者机构：

关键词： Green chemistry; Deep eutectic solvent; Lipase; Biocatalysis; Biocompatibility

期刊名称：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY （ 影响因子：4.813； 五年影响因子：4.697 ）

ISSN： 0175-7598

年卷期： 2020 年 104 卷 4 期

页码：

收录情况： SCI

摘要： Biocatalysis is a green and sustainable technology for which the ideal solvent should be nontoxic, biocompatible, biodegradable, and sustainable, in addition to supporting high enzyme activity and stability. Deep eutectic solvents (DESs), a novel class of green solvents, have recently emerged as excellent alternatives for use in various biocatalytic reactions and, in particular, in lipase-catalyzed reactions with enzymes. This review discusses the achievements that have been made so far in the use of DESs as reaction media for lipase-catalyzed reactions. In addition, the application of DESs in esterification, transesterification, and amidation reactions with isolated or immobilized biocatalysts, toward enabling the synthesis of biodiesels, sugar esters, phenolipids, and fatty acyl ethanolamides, is summarized, while advances in lipase-catalyzed chemoenzymatic epoxidation reactions, C-C bond-forming Aldol reactions, and hydrolysis reactions in DESs are also discussed. This review also summarize some remaining questions concerning the use of DESs, including the intriguing role of water as a cosolvent in biocatalytic reactions carried out in DESs, and the relationship between the nature of the DESs and their influence on the enzyme stability and activity at the molecular level.

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