A review of bioselenol-specific fluorescent probes: Synthesis, properties, and imaging applications

文献类型： 外文期刊

第一作者： Liu, Yuning

作者： Liu, Yuning;Feng, Xiaohui;Yu, Yanan;Zhao, Qingyu;Tang, Chaohua;Zhang, Junmin;Liu, Yuning;Feng, Xiaohui;Yu, Yanan;Zhao, Qingyu;Tang, Chaohua;Zhang, Junmin

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关键词： Selenium; Bioselenol; Fluorescent probe; Selenocysteine; Thioredoxin reductase; Hydrogen selenide

期刊名称：ANALYTICA CHIMICA ACTA （ 影响因子：6.558； 五年影响因子：6.228 ）

ISSN： 0003-2670

年卷期： 2020 年 1110 卷

页码：

收录情况： SCI

摘要： Bioselenols are important substances for the maintenance of physiological balance and offer anticancer properties; however, their causal mechanisms and effectiveness have not been assessed. One way to explore their physiological functions is the in vivo detection of bioselenols at the molecular level, and one of the most efficient ways to do so is to use fluorescent probes. Various types of bioselenol-specific fluorescent probes have been synthesized and optimized using chemical simulations and by improving biothiol fluorescent probes. Here, we review recent advances in bioselenol-specific fluorescent probes for selenocysteine (Sec), thioredoxin reductase (TrxR), and hydrogen selenide (H2Se). In particular, the molecular design principles of different types of bioselenols, their corresponding sensing mechanisms, and imaging applications are summarized. (C) 2020 Published by Elsevier B.V.

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